![]() Our goal was to produce a reference book containing practical reference information useful to practicing toxicologists in the chemical and pharmaceutical industries, contract laboratories, regulatory agencies, and academia. We have attempted to fill this void with this publication. A single basic reference source of toxicological information has not been previously available. Although practicing toxicologists usually can locate information related to their own areas of expertise with minimal effort, obtaining reference information in less familiar areas of toxicology may require considerably more effort, possibly involving a trip to the library or a phone call to a colleague. Diverse information such as normal hematology and clinical chemistry values, reproductive indices, physiological parameters, animal housing requirements, toxicity classifications, and regulatory requirements accumulated during the toxicologist’s career are generally scattered in file cabinets and on office shelves. Preface to the First Edition Toxicologists working in the laboratory or office rely on a large information base to design, conduct, and interpret toxicology studies and to perform risk assessments. Government works International Standard Book Number 0-8493-0370-2 Library of Congress Card Number 2001025086 Printed in the United States of America 1 2 3 4 5 6 7 8 9 0 Printed on acid-free paper Visit the CRC Press Web site at © 2002 by CRC Press LLC No claim to original U.S. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation, without intent to infringe. Corporate Blvd., Boca Raton, Florida 33431. Direct all inquiries to CRC Press LLC, 2000 N.W. Specific permission must be obtained in writing from CRC Press LLC for such copying. The consent of CRC Press LLC does not extend to copying for general distribution, for promotion, for creating new works, or for resale. For organizations that have been granted a photocopy license by the CCC, a separate system of payment has been arranged. The fee is subject to change without notice. The fee code for users of the Transactional Reporting Service is ISBN 0-8493-0370-2/01/$0.00+$1.50. Authorization to photocopy items for internal or personal use, or the personal or internal use of specific clients, may be granted by CRC Press LLC, provided that $1.50 per page photocopied is paid directly to Copyright Clearance Center, 222 Rosewood Drive, Danvers, MA 01923 USA. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage or retrieval system, without prior permission in writing from the publisher. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. Reprinted material is quoted with permission, and sources are indicated. This book contains information obtained from authentic and highly regarded sources. Includes bibliographical references and index. Library of Congress Cataloging-in-Publication Data Handbook of toxicology / Michael J.
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